Items where Author is "Grosso, Giuseppe"

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Scientific Production Open English Epidemiological studies consistently link higher fish intake with slower rates of cognitive decline and lower dementia incidence. The aim of the present study was to systematically review existing observational studies investigating the association between fish consumption and cognitive function in older adults. A total of 25 studies (8 cross-sectional and 17 prospective including mainly healthy older adults, age range of participants ranging from 18 to 30 years at baseline in prospective studies to 65 to 91 years, representing the upper limit of the age spectrum) were reviewed. Cognitive functions currently investigated in most published studies included various domains, such as global cognition, memory (episodic, working), executive function (planning, inhibition, flexibility), attention and processing speed. Existing studies greatly vary in terms of design (cross-sectional and prospective), geographical area, number of participants involved, and tools used to assess the outcomes of interest. The main findings across studies are not univocal, with some studies reporting stronger evidence of association between fish consumption and various cognitive domains, while others addressed rather null findings. The most consistently responsive domains were processing speed, executive functioning, semantic memory, and global cognitive ability among individuals consuming fish at least weekly, which are highly relevant to both neurodegenerative and vascular forms of cognitive impairment. Positive associations were also observed for verbal memory and general memory, though these were less uniform and often attenuated after multivariable adjustment. In contrast, associations with reaction time, verbal-numerical reasoning, and broad composite scores were inconsistent, and several fully adjusted models showed null results. In conclusion, the evidence suggests that regular fish intake (typically ≥1–2 servings per week) is linked to preserved cognitive performance, although some inconsistent findings require further investigations. metadata Godos, Justyna; Caruso, Giuseppe; Micek, Agnieszka; Dolci, Alberto; Rodríguez Velasco, Carmen Lilí; Frias-Toral, Evelyn; Di Giorgio, Jason; Veronese, Nicola; Lehoczki, Andrea; Siervo, Mario; Ungvari, Zoltan and Grosso, Giuseppe mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, carmen.rodriguez@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2026) Fish consumption and cognitive function in aging: a systematic review of observational studies. GeroScience. ISSN 2509-2723

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Scientific Production
University of La Romana > Research > Scientific Production Closed English Food security is a universal need worldwide. This study explored the relationship between food security and adherence to the Mediterranean diet in the context of the DELICIOUS project. A survey involving 2,011 parents of children and adolescents aged 6–17 years was conducted. Adherence to the Mediterranean diet was assessed through the KIDMED score. Information regarding the ease of accessing Mediterranean foods, economic allowance, employment and residence was collected. Logistic regressions analyses were performed to test the associations. Individuals living in rural areas and reporting difficulty in obtaining all studied foods were less likely to follow the Mediterranean diet. Higher adherence was associated with a household monthly income higher than €4000. No associations with family status and no differences across countries were found. The progressive shift away from the Mediterranean diet may depend not only on cultural preferences for unhealthier, industrial alternatives but also on family budgets and food accessibility. metadata Scazzina, Francesca; Rosi, Alice; Giampieri, Francesca; Poveda-Loor, Carlos; Abdelkarim, Osama; Aly, Mohamed; Frias-Toral, Evelyn; Pons, Juancho; Vázquez-Araújo, Laura; Sumalla Cano, Sandra; Elío Pascual, Iñaki; Monasta, Lorenzo; Paladino, Nadia; Mata, Ana; Chacón, Adrián; Busó, Pablo and Grosso, Giuseppe mail UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2025) Socio-economic status, food security and adherence to the Mediterranean diet in five Mediterranean countries: the DELICIOUS project. International Journal of Food Sciences and Nutrition, 76 (8). pp. 869-877. ISSN 0963-7486

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Scientific Production
University of La Romana > Research > Scientific Production Open English Background: Nut consumption has been considered a potential protective factor against cognitive decline. The aim of this study was to test whether higher total and specific nut intake was associated with better cognitive status in a sample of older Italian adults. Methods: A cross-sectional analysis on 883 older adults (>50 y) was conducted. A 110-item food frequency questionnaire was used to collect information on the consumption of various types of nuts. The Short Portable Mental Status Questionnaire was used to assess cognitive status. Multivariate logistic regression analyses were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between nut intake and cognitive status after adjusting for potential confounding factors. Results: The median intake of total nuts was 11.7 g/day and served as a cut-off to categorize low and high consumers (mean intake 4.3 g/day vs. 39.7 g/day, respectively). Higher total nut intake was significantly associated with a lower prevalence of impaired cognitive status among older individuals (OR = 0.35, CI 95%: 0.15, 0.84) after adjusting for potential confounding factors. Notably, this association remained significant after additional adjustment for adherence to the Mediterranean dietary pattern as an indicator of diet quality, (OR = 0.32, CI 95%: 0.13, 0.77). No significant associations were found between cognitive status and specific types of nuts. Conclusions: Habitual nut intake is associated with better cognitive status in older adults. metadata Godos, Justyna; Giampieri, Francesca; Frias-Toral, Evelyn; Zambrano-Villacres, Raynier; Rojas Vistorte, Angel Olider; Yélamos Torres, Vanessa; Battino, Maurizio; Galvano, Fabio; Castellano, Sabrina and Grosso, Giuseppe mail UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, angel.rojas@uneatlantico.es, vanessa.yelamos@funiber.org, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2025) Nut Consumption Is Associated with Cognitive Status in Southern Italian Adults. Nutrients, 17 (3). p. 521. ISSN 2072-6643

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Scientific Production
University of La Romana > Research > Scientific Production Open English Background/Objectives. Traditional dietary patterns are being abandoned in Mediterranean countries, especially among younger generations. This study aimed to investigate the potential lifestyle determinants that can increase adherence to the Mediterranean diet in children and adolescents. Methods. This study is a cross-sectional analysis of data from five Mediterranean countries (Italy, Spain, Portugal, Egypt, and Lebanon) within the context of the EU-funded project DELICIOUS (UnDErstanding consumer food choices & promotion of healthy and sustainable Mediterranean Diet and LIfestyle in Children and adolescents through behavIOUral change actionS). This study comprised information on 2011 children and adolescents aged 6–17 years old collected during 2023. The main background characteristics of both children and parents, including age, sex, education, and family situation, were collected. Children’s eating (i.e., breakfast, place of eating, etc.) and lifestyle habits (i.e., physical activity level, sleep, and screen time) were also investigated. The level of adherence to the Mediterranean diet was assessed using the KIDMED index. Logistic regression analyses were performed to test for likelihood of higher adherence to the Mediterranean diet. Results. Major determinants of higher adherence to the Mediterranean diet were younger age, higher physical activity level, adequate sleep duration, and, among dietary habits, having breakfast and eating with family members and at school. Parents’ younger age and higher education were also determinants of higher adherence. Multivariate adjusted analyses showed that an overall healthier lifestyle and parents’ education were the factors independently associated with higher adherence to the Mediterranean diet. Conclusions. Higher adherence to the Mediterranean diet in children and adolescents living in the Mediterranean area is part of an overall healthy lifestyle possibly depending on parents’ cultural background. metadata Rosi, Alice; Scazzina, Francesca; Giampieri, Francesca; Álvarez-Córdova, Ludwig; Abdelkarim, Osama; Ammar, Achraf; Aly, Mohamed; Frias-Toral, Evelyn; Pons, Juancho; Vázquez-Araújo, Laura; Rodríguez Velasco, Carmen Lilí; Brito Ballester, Julién; Monasta, Lorenzo; Mata, Ana; Chacón, Adrián; Busó, Pablo and Grosso, Giuseppe mail UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, carmen.rodriguez@uneatlantico.es, julien.brito@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2024) Lifestyle Factors Associated with Children’s and Adolescents’ Adherence to the Mediterranean Diet Living in Mediterranean Countries: The DELICIOUS Project. Nutrients, 17 (1). p. 26. ISSN 2072-6643

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Scientific Production
University of La Romana > Research > Scientific Production Open English Cardiovascular diseases (CVDs) are one of the main causes of mortality and morbidity worldwide. A healthy diet rich in plant-derived compounds such as (poly)phenols appears to have a key role in improving cardiovascular health. Flavan-3-ols represent a subclass of (poly)phenols of great interest for their possible health benefits. In this review, we summarized the results of clinical studies on vascular outcomes of flavan-3-ol supplementation and we focused on the role of the microbiota in CVD. Clinical trials included in this review showed that supplementation with flavan-3-ols mostly derived from cocoa products significantly reduces blood pressure and improves endothelial function. Studies on catechins from green tea demonstrated better results when involving healthy individuals. From a mechanistic point of view, emerging evidence suggests that microbial metabolites may play a role in the observed effects. Their function extends beyond the previous belief of ROS scavenging activity and encompasses a direct impact on gene expression and protein function. Although flavan-3-ols appear to have effects on cardiovascular health, further studies are needed to clarify and confirm these potential benefits and the rising evidence of the potential involvement of the microbiota. metadata Godos, Justyna; Romano, Giovanni Luca; Laudani, Samuele; Gozzo, Lucia; Guerrera, Ida; Dominguez Azpíroz, Irma; Martínez Díaz, Raquel; Quiles, José L.; Battino, Maurizio; Drago, Filippo; Giampieri, Francesca; Galvano, Fabio and Grosso, Giuseppe mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, irma.dominguez@unini.edu.mx, raquel.martinez@uneatlantico.es, jose.quiles@uneatlantico.es, maurizio.battino@uneatlantico.es, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2024) Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action. Nutrients, 16 (15). p. 2471. ISSN 2072-6643

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Articles and Books Open English Over the last decades, the Mediterranean diet gained enormous scientific, social, and commercial attention due to proven positive effects on health and undeniable taste that facilitated a widespread popularity. Researchers have investigated the role of Mediterranean-type dietary patterns on human health all around the world, reporting consistent findings concerning its benefits. However, what does truly define the Mediterranean diet? The myriad of dietary scores synthesizes the nutritional content of a Mediterranean-type diet, but a variety of aspects are generally unexplored when studying the adherence to this dietary pattern. Among dietary factors, the main characteristics of the Mediterranean diet, such as consumption of fruit and vegetables, olive oil, and cereals should be accompanied by other underrated features, such as the following: (i) specific reference to whole-grain consumption; (ii) considering the consumption of legumes, nuts, seeds, herbs and spices often untested when exploring the adherence to the Mediterranean diet; (iii) consumption of eggs and dairy products as common foods consumed in the Mediterranean region (irrespectively of the modern demonization of dietary fat intake). Another main feature of the Mediterranean diet includes (red) wine consumption, but more general patterns of alcohol intake are generally unmeasured, lacking specificity concerning the drinking occasion and intensity (i.e., alcohol drinking during meals). Among other underrated aspects, cooking methods are rather simple and yet extremely varied. Several underrated aspects are related to the quality of food consumed when the Mediterranean diet was first investigated: foods are locally produced, minimally processed, and preserved with more natural methods (i.e., fermentation), strongly connected with the territory with limited and controlled impact on the environment. Dietary habits are also associated with lifestyle behaviors, such as sleeping patterns, and social and cultural values, favoring commensality and frugality. In conclusion, it is rather reductive to consider the Mediterranean diet as just a pattern of food groups to be consumed decontextualized from the social and geographical background of Mediterranean culture. While the methodologies to study the Mediterranean diet have demonstrated to be useful up to date, a more holistic approach should be considered in future studies by considering the aforementioned underrated features and values to be potentially applied globally through the concept of a “Planeterranean” diet. metadata Godos, Justyna; Scazzina, Francesca; Paternò Castello, Corrado; Giampieri, Francesca; Quiles, José L.; Briones Urbano, Mercedes; Battino, Maurizio; Galvano, Fabio; Iacoviello, Licia; de Gaetano, Giovanni; Bonaccio, Marialaura and Grosso, Giuseppe mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, jose.quiles@uneatlantico.es, mercedes.briones@uneatlantico.es, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2024) Underrated aspects of a true Mediterranean diet: understanding traditional features for worldwide application of a “Planeterranean” diet. Journal of Translational Medicine, 22 (1). ISSN 1479-5876

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Scientific Production
University of La Romana > Research > Scientific Production Open English Isoflavones are a group of (poly)phenols, also defined as phytoestrogens, with chemical structures comparable with estrogen, that exert weak estrogenic effects. These phytochemical compounds have been targeted for their proven antioxidant and protective effects. Recognizing the increasing prevalence of cardiovascular diseases (CVD), there is a growing interest in understanding the potential cardiovascular benefits associated with these phytochemical compounds. Gut microbiota may play a key role in mediating the effects of isoflavones on vascular and endothelial functions, as it is directly implicated in isoflavones metabolism. The findings from randomized clinical trials indicate that isoflavone supplementation may exert putative effects on vascular biomarkers among healthy individuals, but not among patients affected by cardiometabolic disorders. These results might be explained by the enzymatic transformation to which isoflavones are subjected by the gut microbiota, suggesting that a diverse composition of the microbiota may determine the diverse bioavailability of these compounds. Specifically, the conversion of isoflavones in equol—a microbiota-derived metabolite—seems to differ between individuals. Further studies are needed to clarify the intricate molecular mechanisms behind these contrasting results. metadata Laudani, Samuele; Godos, Justyna; Romano, Giovanni Luca; Gozzo, Lucia; Di Domenico, Federica Martina; Dominguez Azpíroz, Irma; Martínez Díaz, Raquel; Giampieri, Francesca; Quiles, José L.; Battino, Maurizio; Drago, Filippo; Galvano, Fabio and Grosso, Giuseppe mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, irma.dominguez@unini.edu.mx, raquel.martinez@uneatlantico.es, francesca.giampieri@uneatlantico.es, jose.quiles@uneatlantico.es, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2024) Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? Pharmaceuticals, 17 (2). p. 236. ISSN 1424-8247

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Articles and Books
Universidad Internacional do Cuanza > Research > Scientific Production
University of La Romana > Research > Scientific Production Open English The prevalence of sleep disorders, characterized by issues with quality, timing, and sleep duration is increasing globally. Among modifiable risk factors, diet quality has been suggested to influence sleep features. The Mediterranean diet is considered a landmark dietary pattern in terms of quality and effects on human health. However, dietary habits characterized by this cultural heritage should also be considered in the context of overall lifestyle behaviors, including sleep habits. This study aimed to systematically revise the literature relating to adherence to the Mediterranean diet and sleep features in observational studies. The systematic review comprised 23 reports describing the relation between adherence to the Mediterranean diet and different sleep features, including sleep quality, sleep duration, daytime sleepiness, and insomnia symptoms. The majority of the included studies were conducted in the Mediterranean basin and reported a significant association between a higher adherence to the Mediterranean diet and a lower likelihood of having poor sleep quality, inadequate sleep duration, excessive daytime sleepiness or symptoms of insomnia. Interestingly, additional studies conducted outside the Mediterranean basin showed a relationship between the adoption of a Mediterranean-type diet and sleep quality, suggesting that biological mechanisms sustaining such an association may exist. In conclusion, current evidence suggests a relationship between adhering to the Mediterranean diet and overall sleep quality and different sleep parameters. The plausible bidirectional association should be further investigated to understand whether the promotion of a healthy diet could be used as a tool to improve sleep quality. metadata Godos, Justyna; Ferri, Raffaele; Lanza, Giuseppe; Caraci, Filippo; Rojas Vistorte, Angel Olider; Yélamos Torres, Vanessa; Grosso, Giuseppe and Castellano, Sabrina mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, angel.rojas@uneatlantico.es, vanessa.yelamos@funiber.org, UNSPECIFIED, UNSPECIFIED (2024) Mediterranean Diet and Sleep Features: A Systematic Review of Current Evidence. Nutrients, 16 (2). p. 282. ISSN 2072-6643