eprintid: 9375 rev_number: 7 eprint_status: archive userid: 2 dir: disk0/00/00/93/75 datestamp: 2023-10-25 23:30:22 lastmod: 2023-10-25 23:30:22 status_changed: 2023-10-25 23:30:22 type: article metadata_visibility: show creators_name: Cianciosi, Danila creators_name: Diaz, Yasmany Armas creators_name: Gaddi, Antonio Vittorino creators_name: Capello, Fabio creators_name: Savo, Maria Teresa creators_name: Pali-Casanova, Ramón creators_name: Martínez Espinosa, Julio César creators_name: Pascual Barrera, Alina Eugenia creators_name: Navarro‐Hortal, Maria‐Dolores creators_name: Tian, Lingmin creators_name: Bai, Weibin creators_name: Giampieri, Francesca creators_name: Battino, Maurizio creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: ramon.pali@unini.edu.mx creators_id: ulio.martinez@unini.edu.mx creators_id: alina.pascual@unini.edu.mx creators_id: creators_id: creators_id: creators_id: francesca.giampieri@uneatlantico.es creators_id: title: Can alpha‐linolenic acid be a modulator of “cytokine storm,” oxidative stress and immune response in SARS‐CoV‐2 infection? ispublished: pub subjects: uneat_sn divisions: uneatlantico_produccion_cientifica divisions: unincol_produccion_cientifica divisions: uninimx_produccion_cientifica divisions: uninipr_produccion_cientifica full_text_status: none keywords: lpha-linolenic acid; COVID-19; cytokine storm; inflammation; oxidative stress; SARS-CoV-2 abstract: Alpha-linolenic acid (ALA) is a long-chain polyunsaturated essential fatty acid of the Ω3 series found mainly in vegetables, especially in the fatty part of oilseeds, dried fruit, berries, and legumes. It is very popular for its preventive use in several diseases: It seems to reduce the risk of the onset or decrease some phenomena related to inflammation, oxidative stress, and conditions of dysregulation of the immune response. Recent studies have confirmed these unhealthy situations also in patients with severe coronavirus disease 2019 (COVID-19). Different findings (in vitro, in vivo, and clinical ones), summarized and analyzed in this review, have showed an important role of ALA in other various non-COVID physiological and pathological situations against “cytokines storm,” chemokines secretion, oxidative stress, and dysregulation of immune cells that are also involved in the infection of the 2019 novel coronavirus. According to the effects of ALA against all the aforementioned situations (also present in patients with a severe clinical picture of severe acute respiratory syndrome-(CoV-2) infection), there may be the biologic plausibility of a prophylactic effect of this compound against COVID-19 symptoms and fatality. date: 2023-10 publication: Food Frontiers id_number: doi:10.1002/fft2.319 refereed: TRUE issn: 2643-8429 official_url: http://doi.org/10.1002/fft2.319 access: open language: en citation: Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica Universidad Internacional Iberoamericana México > Investigación > Producción Científica Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Abierto Inglés Alpha-linolenic acid (ALA) is a long-chain polyunsaturated essential fatty acid of the Ω3 series found mainly in vegetables, especially in the fatty part of oilseeds, dried fruit, berries, and legumes. It is very popular for its preventive use in several diseases: It seems to reduce the risk of the onset or decrease some phenomena related to inflammation, oxidative stress, and conditions of dysregulation of the immune response. Recent studies have confirmed these unhealthy situations also in patients with severe coronavirus disease 2019 (COVID-19). Different findings (in vitro, in vivo, and clinical ones), summarized and analyzed in this review, have showed an important role of ALA in other various non-COVID physiological and pathological situations against “cytokines storm,” chemokines secretion, oxidative stress, and dysregulation of immune cells that are also involved in the infection of the 2019 novel coronavirus. According to the effects of ALA against all the aforementioned situations (also present in patients with a severe clinical picture of severe acute respiratory syndrome-(CoV-2) infection), there may be the biologic plausibility of a prophylactic effect of this compound against COVID-19 symptoms and fatality. metadata Cianciosi, Danila; Diaz, Yasmany Armas; Gaddi, Antonio Vittorino; Capello, Fabio; Savo, Maria Teresa; Pali-Casanova, Ramón; Martínez Espinosa, Julio César; Pascual Barrera, Alina Eugenia; Navarro‐Hortal, Maria‐Dolores; Tian, Lingmin; Bai, Weibin; Giampieri, Francesca y Battino, Maurizio mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, ramon.pali@unini.edu.mx, ulio.martinez@unini.edu.mx, alina.pascual@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, SIN ESPECIFICAR (2023) Can alpha‐linolenic acid be a modulator of “cytokine storm,” oxidative stress and immune response in SARS‐CoV‐2 infection? Food Frontiers. ISSN 2643-8429