TY  - JOUR
A1  - Cianciosi, Danila
A1  - Armas Diaz, Yasmany
A1  - Alvarez-Suarez, José M.
A1  - Chen, Xiumin
A1  - Zhang, Di
A1  - Martínez López, Nohora Milena
A1  - Briones Urbano, Mercedes
A1  - Quiles, José L.
A1  - Amici, Adolfo
A1  - Battino, Maurizio
A1  - Giampieri, Francesca
AV  - none
VL  - 427
SN  - 03088146
N2  - Manuka honey, which is rich in pinocembrin, quercetin, naringenin, salicylic, p-coumaric, ferulic, syringic and 3,4-dihydroxybenzoic acids, has been shown to have pleiotropic effects against colon cancer cells. In this study, potential chemosensitizing effects of Manuka honey against 5-Fluorouracil were investigated in colonspheres enriched with cancer stem cells (CSCs), which are responsible for chemoresistance. Results showed that 5-Fluorouracil increased when it was combined with Manuka honey by downregulating the gene expression of both ATP-binding cassette sub-family G member 2, an efflux pump and thymidylate synthase, the main target of 5-Fluorouracil which regulates the ex novo DNA synthesis. Manuka honey was associated with decreased self-renewal ability by CSCs, regulating expression of several genes in Wnt/?-catenin, Hedgehog and Notch pathways. This preliminary study opens new areas of research into the effects of natural compounds in combination with pharmaceuticals and, potentially, increase efficacy or reduce adverse effects.
UR  - http://doi.org/10.1016/j.foodchem.2023.136684
Y1  - 2023/11//
TI  - Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal
JF  - Food Chemistry
ID  - uninipr7844
ER  -