<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal"^^ . "Manuka honey, which is rich in pinocembrin, quercetin, naringenin, salicylic, p-coumaric, ferulic, syringic and 3,4-dihydroxybenzoic acids, has been shown to have pleiotropic effects against colon cancer cells. In this study, potential chemosensitizing effects of Manuka honey against 5-Fluorouracil were investigated in colonspheres enriched with cancer stem cells (CSCs), which are responsible for chemoresistance. Results showed that 5-Fluorouracil increased when it was combined with Manuka honey by downregulating the gene expression of both ATP-binding cassette sub-family G member 2, an efflux pump and thymidylate synthase, the main target of 5-Fluorouracil which regulates the ex novo DNA synthesis. Manuka honey was associated with decreased self-renewal ability by CSCs, regulating expression of several genes in Wnt/β-catenin, Hedgehog and Notch pathways. This preliminary study opens new areas of research into the effects of natural compounds in combination with pharmaceuticals and, potentially, increase efficacy or reduce adverse effects."^^ . "2023-11" . . "427" . . "Food Chemistry"^^ . . . "03088146" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Maurizio"^^ . "Battino"^^ . "Maurizio Battino"^^ . . "Nohora Milena"^^ . "Martínez López"^^ . "Nohora Milena Martínez López"^^ . . "Mercedes"^^ . "Briones Urbano"^^ . "Mercedes Briones Urbano"^^ . . "José L."^^ . "Quiles"^^ . "José L. Quiles"^^ . . "Danila"^^ . "Cianciosi"^^ . "Danila Cianciosi"^^ . . "Francesca"^^ . "Giampieri"^^ . "Francesca Giampieri"^^ . . "Yasmany"^^ . "Armas Diaz"^^ . "Yasmany Armas Diaz"^^ . . "Di"^^ . "Zhang"^^ . "Di Zhang"^^ . . "José M."^^ . "Alvarez-Suarez"^^ . "José M. Alvarez-Suarez"^^ . . "Adolfo"^^ . "Amici"^^ . "Adolfo Amici"^^ . . "Xiumin"^^ . "Chen"^^ . "Xiumin Chen"^^ . . . . . "HTML Summary of #7844 \n\nCan the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal\n\n" . "text/html" . . . "Nutrition"@en . "Alimentación"@es . .