@article{uninipr7844,
          author = {Danila Cianciosi and Yasmany Armas Diaz and Jos{\'e} M. Alvarez-Suarez and Xiumin Chen and Di Zhang and Nohora Milena Mart{\'i}nez L{\'o}pez and Mercedes Briones Urbano and Jos{\'e} L. Quiles and Adolfo Amici and Maurizio Battino and Francesca Giampieri},
          volume = {427},
            year = {2023},
         journal = {Food Chemistry},
           title = {Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal},
           pages = {136684},
           month = {Noviembre},
             url = {http://repositorio.unib.org/id/eprint/7844/},
        abstract = {Manuka honey, which is rich in pinocembrin, quercetin, naringenin, salicylic, p-coumaric, ferulic, syringic and 3,4-dihydroxybenzoic acids, has been shown to have pleiotropic effects against colon cancer cells. In this study, potential chemosensitizing effects of Manuka honey against 5-Fluorouracil were investigated in colonspheres enriched with cancer stem cells (CSCs), which are responsible for chemoresistance. Results showed that 5-Fluorouracil increased when it was combined with Manuka honey by downregulating the gene expression of both ATP-binding cassette sub-family G member 2, an efflux pump and thymidylate synthase, the main target of 5-Fluorouracil which regulates the ex novo DNA synthesis. Manuka honey was associated with decreased self-renewal ability by CSCs, regulating expression of several genes in Wnt/{\ensuremath{\beta}}-catenin, Hedgehog and Notch pathways. This preliminary study opens new areas of research into the effects of natural compounds in combination with pharmaceuticals and, potentially, increase efficacy or reduce adverse effects.}
}