eprintid: 5929 rev_number: 8 eprint_status: archive userid: 2 dir: disk0/00/00/59/29 datestamp: 2023-02-17 23:30:07 lastmod: 2023-02-17 23:30:08 status_changed: 2023-02-17 23:30:07 type: article metadata_visibility: show creators_name: Romero-Márquez, Jose M. creators_name: Navarro-Hortal, María D. creators_name: Orantes, Francisco J. creators_name: Esteban-Muñoz, Adelaida creators_name: Mazas Pérez-Oleaga, Cristina creators_name: Battino, Maurizio creators_name: Sánchez-González, Cristina creators_name: Rivas-García, Lorenzo creators_name: Giampieri, Francesca creators_name: Quiles, José L. creators_name: Forbes-Hernandez, Tamara Y. creators_id: creators_id: creators_id: creators_id: creators_id: cristina.mazas@uneatlantico.es creators_id: maurizio.battino@uneatlantico.es creators_id: creators_id: creators_id: francesca.giampieri@uneatlantico.es creators_id: jose.quiles@uneatlantico.es creators_id: tamara.forbes@unini.edu.mx title: In Vivo Anti-Alzheimer and Antioxidant Properties of Avocado (Persea americana Mill.) Honey from Southern Spain ispublished: pub subjects: uneat_sn divisions: uneatlantico_produccion_cientifica divisions: uninipr_produccion_cientifica divisions: unic_produccion_cientifica full_text_status: public keywords: Aβ; tau; AAPH; oxidative stress; ROS; phytochemical; Alzheimer; tauopathies abstract: There is growing evidence that Alzheimer’s disease (AD) can be prevented by reducing risk factors involved in its pathophysiology. Food-derived bioactive molecules can help in the prevention and reduction of the progression of AD. Honey, a good source of antioxidants and bioactive molecules, has been tied to many health benefits, including those from neurological origin. Monofloral avocado honey (AH) has recently been characterized but its biomedical properties are still unknown. The aim of this study is to further its characterization, focusing on the phenolic profile. Moreover, its antioxidant capacity was assayed both in vitro and in vivo. Finally, a deep analysis on the pathophysiological features of AD such as oxidative stress, amyloid-β aggregation, and protein-tau-induced neurotoxicity were evaluated by using the experimental model C. elegans. AH exerted a high antioxidant capacity in vitro and in vivo. No toxicity was found in C. elegans at the dosages used. AH prevented ROS accumulation under AAPH-induced oxidative stress. Additionally, AH exerted a great anti-amyloidogenic capacity, which is relevant from the point of view of AD prevention. AH exacerbated the locomotive impairment in a C. elegans model of tauopathy, although the real contribution of AH remains unclear. The mechanisms under the observed effects might be attributed to an upregulation of daf-16 as well as to a strong ROS scavenging activity. These results increase the interest to study the biomedical applications of AH; however, more research is needed to deepen the mechanisms under the observed effects date: 2023 publication: Antioxidants volume: 12 number: 2 pagerange: 404 id_number: doi:10.3390/antiox12020404 refereed: TRUE issn: 2076-3921 official_url: http://doi.org/10.3390/antiox12020404 access: open language: en citation: Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Universidad Internacional do Cuanza > Investigación > Producción Científica Abierto Inglés There is growing evidence that Alzheimer’s disease (AD) can be prevented by reducing risk factors involved in its pathophysiology. Food-derived bioactive molecules can help in the prevention and reduction of the progression of AD. Honey, a good source of antioxidants and bioactive molecules, has been tied to many health benefits, including those from neurological origin. Monofloral avocado honey (AH) has recently been characterized but its biomedical properties are still unknown. The aim of this study is to further its characterization, focusing on the phenolic profile. Moreover, its antioxidant capacity was assayed both in vitro and in vivo. Finally, a deep analysis on the pathophysiological features of AD such as oxidative stress, amyloid-β aggregation, and protein-tau-induced neurotoxicity were evaluated by using the experimental model C. elegans. AH exerted a high antioxidant capacity in vitro and in vivo. No toxicity was found in C. elegans at the dosages used. AH prevented ROS accumulation under AAPH-induced oxidative stress. Additionally, AH exerted a great anti-amyloidogenic capacity, which is relevant from the point of view of AD prevention. AH exacerbated the locomotive impairment in a C. elegans model of tauopathy, although the real contribution of AH remains unclear. The mechanisms under the observed effects might be attributed to an upregulation of daf-16 as well as to a strong ROS scavenging activity. These results increase the interest to study the biomedical applications of AH; however, more research is needed to deepen the mechanisms under the observed effects metadata Romero-Márquez, Jose M.; Navarro-Hortal, María D.; Orantes, Francisco J.; Esteban-Muñoz, Adelaida; Mazas Pérez-Oleaga, Cristina; Battino, Maurizio; Sánchez-González, Cristina; Rivas-García, Lorenzo; Giampieri, Francesca; Quiles, José L. y Forbes-Hernandez, Tamara Y. mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, jose.quiles@uneatlantico.es, tamara.forbes@unini.edu.mx (2023) In Vivo Anti-Alzheimer and Antioxidant Properties of Avocado (Persea americana Mill.) Honey from Southern Spain. Antioxidants, 12 (2). p. 404. ISSN 2076-3921 document_url: http://repositorio.unib.org/id/eprint/5929/1/antioxidants-12-00404.pdf