TY - JOUR A1 - Rustam, Furqan A1 - Aslam, Naila A1 - De La Torre Díez, Isabel A1 - Khan, Yaser Daanial A1 - Vidal Mazón, Juan Luis A1 - Rodríguez Velasco, Carmen Lilí A1 - Ashraf, Imran IS - 11 AV - public TI - White Blood Cell Classification Using Texture and RGB Features of Oversampled Microscopic Images Y1 - 2022/11// N2 - White blood cell (WBC) type classification is a task of significant importance for diagnosis using microscopic images of WBC, which develop immunity to fight against infections and foreign substances. WBCs consist of different types, and abnormalities in a type of WBC may potentially represent a disease such as leukemia. Existing studies are limited by low accuracy and overrated performance, often caused by model overfit due to an imbalanced dataset. Additionally, many studies consider a lower number of WBC types, and the accuracy is exaggerated. This study presents a hybrid feature set of selective features and synthetic minority oversampling technique-based resampling to mitigate the influence of the above-mentioned problems. Furthermore, machine learning models are adopted for being less computationally complex, requiring less data for training, and providing robust results. Experiments are performed using both machine- and deep learning models for performance comparison using the original dataset, augmented dataset, and oversampled dataset to analyze the performances of the models. The results suggest that a hybrid feature set of both texture and RGB features from microscopic images, selected using Chi2, produces a high accuracy of 0.97 with random forest. Performance appraisal using k-fold cross-validation and comparison with existing state-of-the-art studies shows that the proposed approach outperforms existing studies regarding the obtained accuracy and computational complexity. KW - white blood cells classification; leukemia; texture features; Chi-squared; SMOTE ID - uninipr4607 JF - Healthcare SN - 2227-9032 UR - http://doi.org/10.3390/healthcare10112230 VL - 10 ER -