eprintid: 11265 rev_number: 9 eprint_status: archive userid: 2 dir: disk0/00/01/12/65 datestamp: 2024-03-14 23:30:27 lastmod: 2024-03-14 23:30:28 status_changed: 2024-03-14 23:30:27 type: article metadata_visibility: show creators_name: Cassotta, Manuela creators_name: Cianciosi, Danila creators_name: Elexpuru Zabaleta, Maria creators_name: Elío Pascual, Iñaki creators_name: Sumalla Cano, Sandra creators_name: Giampieri, Francesca creators_name: Battino, Maurizio creators_id: manucassotta@gmail.com creators_id: creators_id: maria.elexpuru@uneatlantico.es creators_id: inaki.elio@uneatlantico.es creators_id: sandra.sumalla@uneatlantico.es creators_id: francesca.giampieri@uneatlantico.es creators_id: maurizio.battino@uneatlantico.es title: Human‐based new approach methodologies to accelerate advances in nutrition research ispublished: pub subjects: uneat_sn divisions: uneatlantico_produccion_cientifica divisions: unincol_produccion_cientifica divisions: uninimx_produccion_cientifica divisions: uninipr_produccion_cientifica divisions: unic_produccion_cientifica full_text_status: public keywords: alternatives to animal testing, food-risk assessment, human-based research, NAMs, newapproachmethodologies, novelfoodproducts, nutritionresearch abstract: Much of nutrition research has been conventionally based on the use of simplistic in vitro systems or animal models, which have been extensively employed in an effort to better understand the relationships between diet and complex diseases as well as to evaluate food safety. Although these models have undeniably contributed to increase our mechanistic understanding of basic biological processes, they do not adequately model complex human physiopathological phenomena, creating concerns about the translatability to humans. During the last decade, extraordinary advancement in stem cell culturing, three-dimensional cell cultures, sequencing technologies, and computer science has occurred, which has originated a wealth of novel human-based and more physiologically relevant tools. These tools, also known as “new approach methodologies,” which comprise patient-derived organoids, organs-on-chip, multi-omics approach, along with computational models and analysis, represent innovative and exciting tools to forward nutrition research from a human-biology-oriented perspective. After considering some shortcomings of conventional in vitro and vivo approaches, here we describe the main novel available and emerging tools that are appropriate for designing a more human-relevant nutrition research. Our aim is to encourage discussion on the opportunity to explore innovative paths in nutrition research and to promote a paradigm-change toward a more human biology-focused approach to better understand human nutritional pathophysiology, to evaluate novel food products, and to develop more effective targeted preventive or therapeutic strategies while helping in reducing the number and replacing animals employed in nutrition research. date: 2024-03 publication: Food Frontiers pagerange: 1-32 id_number: doi:10.1002/fft2.369 refereed: TRUE issn: 2643-8429 official_url: http://doi.org/10.1002/fft2.369 access: open language: en citation: Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica Universidad Internacional Iberoamericana México > Investigación > Producción Científica Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Universidad Internacional do Cuanza > Investigación > Producción Científica Abierto Inglés Much of nutrition research has been conventionally based on the use of simplistic in vitro systems or animal models, which have been extensively employed in an effort to better understand the relationships between diet and complex diseases as well as to evaluate food safety. Although these models have undeniably contributed to increase our mechanistic understanding of basic biological processes, they do not adequately model complex human physiopathological phenomena, creating concerns about the translatability to humans. During the last decade, extraordinary advancement in stem cell culturing, three-dimensional cell cultures, sequencing technologies, and computer science has occurred, which has originated a wealth of novel human-based and more physiologically relevant tools. These tools, also known as “new approach methodologies,” which comprise patient-derived organoids, organs-on-chip, multi-omics approach, along with computational models and analysis, represent innovative and exciting tools to forward nutrition research from a human-biology-oriented perspective. After considering some shortcomings of conventional in vitro and vivo approaches, here we describe the main novel available and emerging tools that are appropriate for designing a more human-relevant nutrition research. Our aim is to encourage discussion on the opportunity to explore innovative paths in nutrition research and to promote a paradigm-change toward a more human biology-focused approach to better understand human nutritional pathophysiology, to evaluate novel food products, and to develop more effective targeted preventive or therapeutic strategies while helping in reducing the number and replacing animals employed in nutrition research. metadata Cassotta, Manuela; Cianciosi, Danila; Elexpuru Zabaleta, Maria; Elío Pascual, Iñaki; Sumalla Cano, Sandra; Giampieri, Francesca y Battino, Maurizio mail manucassotta@gmail.com, SIN ESPECIFICAR, maria.elexpuru@uneatlantico.es, inaki.elio@uneatlantico.es, sandra.sumalla@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2024) Human‐based new approach methodologies to accelerate advances in nutrition research. Food Frontiers. pp. 1-32. ISSN 2643-8429 document_url: http://repositorio.unib.org/id/eprint/11265/1/Food%20Frontiers%20-%202024%20-%20Cassotta%20-%20Human%E2%80%90based%20new%20approach%20methodologies%20to%20accelerate%20advances%20in%20nutrition%20research.pdf